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CD36: bridging metabolism, inflammation, and reproduction
Qian Liu1, Dongyong Yang1, Songchen Cai2,3
1Reproductive Medicine Center, Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China.
Npj Metabolic Health and Disease
|July 16, 2026
Summary
CD36 protein is crucial for successful pregnancy by managing lipid metabolism and inflammation in reproductive tissues. Its dysfunction is linked to pregnancy complications, highlighting its potential as a therapeutic target.
Area of Science:
- Reproductive biology
- Immunology
- Metabolic research
Background:
- Reproductive success depends on integrated metabolic and inflammatory regulation in the ovary, uterus, and placenta.
- CD36, a lipid transporter and immune receptor, connects fatty acid metabolism with lipid-inflammation signaling.
Purpose of the Study:
- To synthesize evidence on CD36's role in oocyte competence, endometrial receptivity, and maternal-fetal signaling.
- To explore CD36's involvement in pregnancy disorders like gestational diabetes and preeclampsia.
- To evaluate CD36 as a potential therapeutic target for pregnancy complications.
Main Methods:
- Literature synthesis of mechanistic studies on CD36 function.
- Analysis of CD36's impact on reproductive tissues and pregnancy outcomes.
- Review of evidence linking CD36 dysregulation to gestational diabetes, preeclampsia, and pregnancy loss.
Main Results:
- CD36 regulates key aspects of female reproduction, including oocyte quality and uterine receptivity.
- CD36 plays a significant role in signaling at the maternal-fetal interface.
- Dysregulated CD36 is associated with major pregnancy complications, such as gestational diabetes and preeclampsia.
Conclusions:
- CD36 is a critical regulator of reproductive processes and maternal-fetal health.
- CD36's multifaceted role in metabolism and immunity makes it a promising therapeutic target for improving pregnancy outcomes.
- Targeting CD36 may offer novel strategies for managing pregnancy-related metabolic and inflammatory disorders.
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