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Association of intraluminal thrombus in thoracoabdominal aortic aneurysms with a blood stasis model
Guangqiang Zhao1,2, Nan Hu1, Peng Wu3
1Department of Vascular Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China.
Objective:
The aim of this study was to perform patient-specific hemodynamic simulations of thoracoabdominal aortic aneurysm (TAAA) models and evaluate the potential for intraluminal thrombus (ILT) formation.
Methods:
Computed Tomography Angiography data from 12 TAAA patients were reconstructed into patient-specific models, which were grouped according to the presence or absence of ILT accumulation. Old blood volume fraction (OBVF) and convergence time were proposed to reveal the association between thrombotic potential and blood stasis in TAAA.
Results:
The aneurysm exhibited high blood stasis compared with other parts. In the ILT group, normalized OBVF and convergence time (a passive-tracer washout time, not a physiological thrombosis timescale) were 76.66% ± 12.38% and 42.58 ± 13.29 s, respectively, whereas in the non-ILT group, they were 21.42% ± 3.39% and 10.93 ± 5.96 s. The OBVF and convergence time were significantly greater in the ILT group than in the non-ILT group (P-values were <0.0001, <0.01), indicating pronounced blood stasis.
Conclusion:
The blood stasis model provides a new and intuitive approach for clinicians to diagnose and treat ILT in TAAA, offering clearer insights than parameters related to WSS. This model can provide useful guidance for operative planning and postoperative evaluation.
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