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Updated: Aug 6, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

Thiazole-Derived Dual EGFR/CDK-2 Inhibitors: Rational Design, Synthesis, In Vitro Anticancer Evaluation, Mechanistic

Rowida Nasr1, Mohamed S Nafie2,3, Hesham Haffez4,5

  • 1Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

Archiv Der Pharmazie
|July 17, 2026
PubMed

Keywords:
anticancerapoptosiscell cycle arrestdual EGFR/CDK‐2 inhibitionmolecular dockingmolecular dynamics simulationnetwork pharmacologysynthesisthiazole

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