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Updated: Aug 6, 2026

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Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
Published on: March 15, 2024
Transradial Amputation With Nerve Management: Case Presentation and Surgical Technique
Samara Moll1, Jonah Dewing, Gabriel Bouz
1Department of Orthopedic Surgery, NYU Langone Health, New York, NY.
Journal of Orthopaedic Trauma
|July 17, 2026
Summary
This case study shows that combining targeted muscle reinnervation and advanced nerve interfaces in transradial amputation can improve prosthetic function and pain control. This approach optimizes outcomes for traumatic limb loss.
Area of Science:
- Orthopedic Surgery
- Neurology
- Prosthetics & Artificial Limbs
Background:
- Transradial amputation preserves forearm rotation but often results in persistent phantom limb pain and neuropathic issues.
- Current amputation techniques may not fully address nerve-related complications or optimize prosthetic integration.
Purpose of the Study:
- To describe a multidisciplinary approach for transradial amputation integrating advanced nerve management and prosthetic-informed surgical planning.
- To evaluate the efficacy of targeted muscle reinnervation and regenerative peripheral nerve interfaces in managing pain and enhancing prosthetic use.
Main Methods:
- A 29-year-old male patient with a ballistic injury underwent transradial amputation.
- Surgical techniques included targeted muscle reinnervation (TMR), regenerative peripheral nerve interfaces (RPNI), and myodesis.
- Limb length was preserved according to prosthetic guidelines.
Main Results:
- The integrated approach aimed to optimize pain control and prosthetic success.
- Myodesis was performed to enhance residual limb stability and myoelectric signal quality.
- The case highlights improved functional outcomes and quality of life.
Conclusions:
- Transradial amputation, when performed with appropriate length, aids prosthetic use.
- Advanced nerve management and prosthetic-informed surgery are crucial for optimizing outcomes.
- This multidisciplinary strategy offers a promising model for traumatic transradial amputations.
