Related Experiment Video
Updated: Aug 6, 2026
06:57
Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
Published on: September 18, 2016
Trained immunity: An unexplored component of IBD pathogenesis
Michael Doulberis1,2,3, Stergios A Polyzos3,4, Abbas Yadegar5
1Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, 8091, Switzerland.
Inflammatory Bowel Diseases
|July 17, 2026
Summary
Trained immunity (TI) offers a new lens for understanding inflammatory bowel disease (IBD). This innate immune system adaptation may explain IBD persistence and relapse, guiding novel therapeutic strategies.
Area of Science:
- Immunology
- Gastroenterology
- Cellular Biology
Background:
- Trained immunity (TI) involves innate immune memory, offering insights into chronic inflammation.
- Inflammatory bowel disease (IBD) is characterized by chronic gastrointestinal inflammation and relapse.
- The role of TI in IBD pathophysiology is underexplored, despite its potential relevance.
Purpose of the Study:
- To review current insights into the pathogenetic mechanisms of TI in IBD.
- To examine how intestinal factors shape immune cell memory in IBD.
- To discuss the translational implications of TI for IBD management.
Main Methods:
- Narrative review of existing literature on TI and IBD.
- Analysis of immunometabolic and epigenetic reprogramming in immune cells.
- Examination of microbial and metabolic influences in the gut.
Main Results:
- Steady exposure to gut luminal factors may induce proinflammatory immune memory in IBD.
- TI mechanisms may contribute to IBD relapse, even during remission.
- Potential for TI in IBD patient stratification and biomarker discovery.
Conclusions:
- Integrating TI into IBD understanding may reveal new therapeutic targets.
- TI could explain disease persistence and relapse in IBD.
- Further research into TI in IBD is crucial for developing mechanism-based treatments.
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