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Chimeric analysis links increased NO sensitivity to GC-2 domains and higher maximal activity to GC-1

Svenja Stomberg1, Sönke Behrends2

  • 1Department of Pharmacology, Toxicology and Clinical Pharmacy, Technische Universität Braunschweig, Germany.

Biochemical Pharmacology
|July 17, 2026
PubMed
Summary

Soluble guanylyl cyclase (sGC) isoforms α1/β1 and α2/β1 show distinct nitric oxide (NO) responses influenced by cellular environment. Structural domain exchanges reveal complex regulation, suggesting specialized roles in NO signaling.

Keywords:
NO sensitivityNitric oxideSoluble guanylyl cyclasecGMP signalingsGC isoformsα-subunit chimeras

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