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Acute Kidney Injury During Invasive Listeriosis: Frequence, Risk Factors, and Prognostic Impact in a Multicenter
Sylvia Das Neves1, Abderrahmane Bourredjem2, Pascal Chavanet1
1Université Bourgogne Europe, CHU Dijon Bourgogne, Service de maladies infectieuses et tropicales, Dijon, France.
Summary
Acute kidney injury (AKI) affects nearly a third of patients hospitalized with invasive listeriosis. Hypertension and a qSOFA score of 1 or higher predict AKI, which significantly increases mortality risk.
Area of Science:
- Nephrology
- Infectious Diseases
- Critical Care Medicine
Background:
- Invasive listeriosis is a severe infection with high mortality.
- Acute kidney injury (AKI) is a known complication of severe infections, potentially worsening patient outcomes.
- Limited data exists on the incidence, risk factors, and prognostic impact of AKI in invasive listeriosis.
Purpose of the Study:
- To evaluate the incidence of AKI in patients hospitalized with invasive listeriosis.
- To identify predictors of AKI in this patient population.
- To assess the prognostic impact of AKI on mortality in invasive listeriosis.
Main Methods:
- Retrospective multicenter cohort study (2010-2023) of adults with confirmed invasive listeriosis.
- AKI defined by modified KDIGO criteria (≥1.5-fold serum creatinine increase within 14 days).
- Multivariable Cox regression used to identify AKI predictors and assess outcomes.
Main Results:
- 31% of 150 patients developed AKI within 14 days.
- Hypertension (HR 6.60) and qSOFA ≥1 (HR 2.90) were independent predictors of AKI.
- AKI was associated with significantly higher 30-day (37% vs 18%) and 90-day (56% vs 24%) mortality.
Conclusions:
- AKI is a frequent complication of invasive listeriosis.
- Early identification of risk factors like hypertension and qSOFA is crucial for AKI prediction.
- AKI presence portends a worse prognosis, emphasizing the need for renal monitoring in listeriosis patients.
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