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Associations between granulysin and ovarian endometriosis: A 2-sample Mendelian randomization study
Baoyu Lai1, Meixing Yu2, Yunsheng Liao2
1Department of Obstetrics and Gynecology, Guangzhou Medical University, Guangzhou, China.
Medicine
|July 18, 2026
Summary
Granulysin may protect against ovarian endometriosis (EMS), a chronic inflammatory condition. This study suggests a negative causal link, indicating lower granulysin levels might increase EMS risk.
Area of Science:
- Reproductive biology
- Immunology
- Genetics
Background:
- Endometriosis (EMS) is a chronic inflammatory condition.
- Ovarian EMS is the most common form.
- The link between granulysin and ovarian EMS is not well understood.
Purpose of the Study:
- To investigate the potential causal relationship between granulysin and ovarian EMS.
- Utilize Mendelian randomization to assess causality.
Main Methods:
- Two-sample Mendelian randomization analysis.
- Used genome-wide association study data for granulysin and ovarian EMS.
- Employed inverse-variance weighted, weighted median, and MR-Egger methods for validation.
- Performed leave-one-out sensitivity analysis.
Main Results:
- A 1-SD increase in granulysin was associated with a 10.7% reduction in ovarian EMS risk (OR=0.892, 95% CI: 0.824-0.966, P=0.004).
- Findings suggest a negative causal relationship between granulysin expression and ovarian EMS.
Conclusions:
- Granulysin expression appears to have a direct, protective causal effect on ovarian EMS.
- Further research is warranted to explore therapeutic implications.
