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Published on: August 15, 2018
Olduvai domains: humanity's lucky brake
1Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, USA.
Abstract:
Neoteny-a developmental slowdown that results in the retention of juvenile traits into adulthood-has long been viewed as central to human brain expansion. Olduvai domains are proposed here to function as a dosage-dependent metabolic 'brake' that slows development via mitochondrial downregulation. Their human-specific hyperamplification, paired with NOTCH2NL accelerators and new metabolic insights, may solve a century-old evolutionary puzzle.
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