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Updated: Aug 6, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

Clonal Diversity and Genetic Landscape of mecC-Positive S. aureus in Human Samples from Iran: First Report of

Mehdi Goudarzi1, Sima Sadat Seyedjavadi2, Mozhgan Raigani3

  • 1Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Iranian Biomedical Journal
|July 19, 2026
PubMed
Abstract

Insights

MecC-positive Staphylococcus aureus strains show significant biofilm production and antimicrobial resistance, with specific clonal complexes dominating. Continuous monitoring is crucial to prevent transmission and treat infections effectively.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Genetics

Background:

  • Emergence of mecC-carrying Staphylococcus aureus strains poses a significant public health threat.
  • mecC-positive S. aureus isolates are increasingly detected in hospital settings.

Purpose of the Study:

  • To investigate the clonal diversity, genetic traits, antimicrobial resistance, virulence factors, and biofilm formation of mecC-positive S. aureus.
  • To understand the molecular epidemiology of these strains in hospitalized patients in Iran.

Main Methods:

  • Analysis of 45 mecC-positive S. aureus strains from clinical samples.
  • Antimicrobial susceptibility testing, biofilm formation assays, spa typing, and multilocus sequence typing (MLST).
  • PCR detection of resistance, biofilm-related, and virulence genes.

Main Results:

  • A high percentage of isolates (64.4%) exhibited strong biofilm-producing ability.
  • Prevalence of ant(4΄)-Ia and tet(M) genes was high (80% and 73.3%, respectively).
  • MLST identified four main clonal complexes: CC8 (44.4%), CC130 (24.5%), CC121 (17.8%), and CC425 (13.3%), with CC8/ST239 being the most common lineage.

Conclusions:

  • Continuous monitoring of mecC-positive S. aureus genetic diversity and characteristics is essential.
  • Urgent measures are needed to curb the transmission of these resistant strains and manage infections.
Keywords:
HospitalsMethicillin-resistant Staphylococcus aureusStaphylococcus aureus

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