Ventricular Tachycardia Ablation in Structural Heart Disease With LVEF > 35%: Clinical Outcomes and Recurrence
Said-Elias Waezsasa1, Moneeb Khalaph1, Martin Braun1
1Department of Electrophysiology, Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, Germany.
Journal of Cardiovascular Electrophysiology
|July 19, 2026
Summary
Catheter ablation for ventricular tachycardia (VT) in structural heart disease (SHD) patients with preserved ejection fraction is safe but offers moderate control. Outcomes are more favorable for ischemic cardiomyopathy (ICM) than non-ischemic cardiomyopathy (NICM).
Area of Science:
- Cardiology
- Electrophysiology
- Heart Failure
Background:
- Limited data exist on ventricular tachycardia (VT) ablation outcomes in structural heart disease (SHD) patients with moderately impaired left ventricular ejection fraction (LVEF > 35%).
- This study investigates VT recurrence after ablation in a secondary prevention population with sustained VT and LVEF > 35%.
Purpose of the Study:
- To evaluate procedural outcomes and long-term VT recurrence after catheter ablation in SHD patients with LVEF > 35%.
Main Methods:
- Analysis of 219 consecutive SHD patients (LVEF > 35%) undergoing VT ablation.
- Comparison of procedural characteristics, complications, and VT recurrence between ischemic cardiomyopathy (ICM) and non-ischemic cardiomyopathy (NICM) groups.
Main Results:
- VT recurred in 35% of patients, with higher rates in NICM (42%) versus ICM (25%).
- Cardiomyopathy type was the sole independent predictor of VT recurrence (HR 2.312).
- Acute VT non-inducibility correlated with reduced recurrence risk.
Conclusions:
- VT ablation in SHD patients with LVEF > 35% demonstrates acceptable safety and moderate arrhythmia control.
- Outcomes are more favorable in ICM compared to NICM, highlighting varied arrhythmic risk in this population.
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