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Updated: Aug 6, 2026
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Electric and Magnetic Field Devices for Stimulation of Biological Tissues
Published on: May 15, 2021
Wireless Magnetoelectric Stimulation Platform Orchestrating Multicellular Coupling in Complex Neurovascularized
Hongjian Zhang1,2, Polina V Chernozem3, Roman A Surmenev3
1State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai200050, P. R. China.
ACS Nano
|July 20, 2026
Summary
This study introduces a novel magnetoelectric implant for bone regeneration. The wireless electrical stimulation promotes nerve and bone growth, offering a minimally invasive therapeutic approach.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Bioelectronics
Background:
- Bone regeneration is complex, with nerves significantly influencing osteogenesis.
- Conventional therapies for bone repair are often invasive.
- Bioelectric implants offer wireless electrical stimulation (ES) as an alternative.
Purpose of the Study:
- To develop a lead-free magnetoelectric (ME) implant for wireless ES.
- To enhance neurovascularized bone regeneration.
- To explore applications beyond bone repair, including neurological disorders and brain-machine interfaces.
Main Methods:
- Fabrication of a MnFe2O4@Ba0.85Ca0.15Zr0.1Ti0.9O3 (MFO@BCZT) ME nanoheterostructure within a 3D-printed hydrogel.
- Wireless electrical stimulation via magnetic field induction (20 mT, 50 Hz).
- In vivo assessment of neurogenesis, osteogenesis, and related signaling pathways.
Main Results:
- The ME implant generated electrical signals under magnetic stimulation, activating neurogenesis and osteogenesis pathways.
- In vivo implantation led to a 3.1-fold increase in innervation and a 4.6-fold increase in bone formation.
- The implant successfully recreated electrophysiological microenvironments, promoting neuroangiogenesis and stem cell recruitment.
Conclusions:
- The developed 3D-printed ME hydrogel implant provides high-performance wireless ES for enhanced bone regeneration.
- This magnetically driven ES strategy serves as a ME-multicellular coupling platform for tissue regeneration.
- The implant offers a versatile foundation for multifunctional wireless bioelectronic interfaces with broad therapeutic potential.
