Related Experiment Video
Updated: Aug 6, 2026
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Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Effect of Membrane Perforations With and Without Collagen Membrane Coverage in Vertical Ridge Augmentation: An
Istvan A Urban1,2, Sándor Farkasdi3, Muhammad H A Saleh2
1Urban Regeneration Institute, Budapest, Hungary.
Clinical Oral Implants Research
|July 20, 2026
Summary
Perforated dPTFE membranes and those with added collagen membranes showed similar bone gain in vertical alveolar ridge augmentation. Membrane perforation or added collagen did not significantly impact bone regeneration outcomes.
Area of Science:
- Oral and Maxillofacial Surgery
- Periodontology
- Biomaterials Science
Background:
- Collagen membranes are proposed to have bioactive roles in bone regeneration.
- Titanium-reinforced dPTFE membranes are used in guided bone regeneration.
- The influence of perforation size and additional collagen membranes on outcomes is not fully understood.
Purpose of the Study:
- To evaluate the effect of perforation size in titanium-reinforced dPTFE membranes on vertical alveolar ridge augmentation (VARA).
- To assess whether adding a collagen membrane over perforated dPTFE membranes improves VARA outcomes.
Main Methods:
- 12 beagle dogs underwent VARA with porcine xenograft using three membrane types: non-perforated dPTFE, perforated dPTFE, and perforated dPTFE with collagen membrane.
- Histomorphometry, micro-CT, and immunohistochemistry were used to analyze new bone formation, graft resorption, and inflammatory markers after 16 weeks.
Main Results:
- All groups achieved approximately 60% new bone area with no significant differences between membrane types.
- Linear vertical bone gain and micro-CT outcomes were comparable across all groups.
- No significant differences in inflammatory cell scores were observed, though plasma cell scores approached borderline significance in the collagen membrane group.
Conclusions:
- Perforated dPTFE membranes provide comparable bone augmentation to non-perforated ones in VARA.
- The addition of a collagen membrane over perforated dPTFE membranes does not enhance vertical alveolar ridge augmentation outcomes.
