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Published on: August 7, 2014
SemProtDB: A Reference Database of Seminal Plasma Proteins
Arabela Guedes de Azevedo Viana1, Camilo Jose Ramirez-Lopez1, Renner Philipe Rodrigues Carvalho1
1Departamento de Biologia Geral, Universidade Federal de Viçosa, Viçosa, Brasil.
Molecular Reproduction and Development
|July 20, 2026
Summary
Seminal plasma proteins are crucial for reproduction. We created SemProtDB, a database centralizing seminal plasma proteome data for domestic mammals to aid fertility research.
Area of Science:
- Reproductive Biology
- Proteomics
- Bioinformatics
Background:
- Seminal plasma proteins are essential for sperm function, fertility, and early embryo development.
- Seminal plasma proteomes exhibit high species-specificity, but data is fragmented.
- Lack of centralized data hinders comparative analysis and biomarker discovery.
Purpose of the Study:
- To develop the first centralized database of seminal plasma proteomes from domestic mammals.
- To facilitate comparative and translational research in reproductive biology.
- To identify conserved fertility-related biomarkers.
Main Methods:
- Consolidated data from 28 studies on 8 major domestic mammal species.
- Compiled nearly 18,000 protein entries.
- Manually curated over 1500 proteins.
- Developed a user-friendly interface linked to external databases (UniProt, NCBI, STRING) and publications.
Main Results:
- Launched SemProtDB (https://semprotdb.org/), the first comprehensive database for domestic mammal seminal plasma proteomes.
- Database includes data for Bos taurus, Bubalus bubalis, Capra hircus, Ovis aries, Equus caballus, Equus asinus, Canis lupus familiaris, and Sus scrofa.
- Provides a valuable resource for researchers in reproductive biology.
Conclusions:
- SemProtDB is an unprecedented resource for studying seminal plasma proteomes across domestic mammals.
- Facilitates comparative analysis to understand molecular mechanisms of fertility.
- Aids in the discovery of conserved fertility biomarkers.