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Published on: November 12, 2015
Corneal Tomography Changes After Simultaneous Topical Application of Cyclosporine and Trehalose in Keratoconus
Rohit Shetty1, Pooja Khamar1, Gairik Kundu1
1Department of Cornea and Refractive Surgery, Narayana Nethralaya Eye Hospital, Bangalore, Karnataka, India.
Purpose:
To assess corneal tomography changes in keratoconus (KC) patients after long-term simultaneous use of topical cyclosporine and trehalose.
Design:
Retrospective observational study.
Methods:
Corneal tomography of 362 eyes with KC was performed using Pentacam (OCULUS Optikgerate Gmbh, Germany) at 1st visit and at the last follow-up. Progression was initially evaluated based on change in maximum keratometry (Kmax). This initial classification was then assessed with an artificial intelligence model of 31 tomography variables of Pentacam to confirm the inference of progression based on Kmax alone.
Results:
The mean follow-up time was 10.8 ± 6.01 months (range: 6 to 36 months). Based on a change in Kmax of 0.75, 1.0 and 1.25D criteria, more than 90% of the eyes were stable for each criterion at the last follow-up (initial classification). The AI model confirmed stability of corneal tomography in more than 95% of the eyes at the last follow-up (final classification).
Conclusion:
Most KC eyes had stable tomography findings between the first and last follow-up. Topical anti-inflammatory regimens may be useful for minimizing or eliminating KC progression.
