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Updated: Aug 6, 2026
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Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
Published on: July 6, 2022
Targeting peptide-mediated nanoparticle transport and antitumor efficacy research based on spatial proteomics
Limin Zhang1, Zhiwei Yin1, Minxuan Wang2
1The University of Hong Kong Shenzhen Institute of Research and Innovation (HKU-SIRI), Shenzhen 518048, P. R. China.
Chemical Communications (Cambridge, England)
|July 20, 2026
Abstract
None:
Nanoparticle-based drugs face challenges of weak spatiotemporal control and difficulty in elucidating their mechanisms of action. We designed a stimulus-responsive delivery system based on targeted peptides and quantum dots (QDs) to achieve synergistic therapy combining sonodynamic therapy (SDT) and immune checkpoint blockade (ICB). Using spatially resolved proteomics technology, we analyzed the mechanism underlying this synergy.
