18F-FDG and 68Ga-Pentixafor PET/CT in a Patient With Castleman Disease

Area of Science:

• Nuclear Medicine
• Oncology
• Radiology

Background:

• Castleman disease (CD) is a rare lymphoproliferative disorder.
• CD requires careful differential diagnosis from lymphoma.
• It is also known as giant lymph node hyperplasia or angiofollicular lymph node hyperplasia.

Purpose of the Study:

• To evaluate the diagnostic performance of 18F-FDG and 68Ga-pentixafor PET/CT.
• To assess the role of these imaging modalities in a patient with Castleman disease.

Main Methods:

• Positron Emission Tomography/Computed Tomography (PET/CT) was performed.
• 18F-FDG and 68Ga-pentixafor were used as radiotracers.
• The imaging focused on multiple cervical lymph nodes.

Main Results:

• Findings from 18F-FDG PET/CT are presented.
• Findings from 68Ga-pentixafor PET/CT are presented.
• The imaging identified Castleman disease involving cervical lymph nodes.

Conclusions:

• 18F-FDG and 68Ga-pentixafor PET/CT can aid in the diagnosis of Castleman disease.
• These advanced imaging techniques are valuable for evaluating lymphoproliferative disorders.
• The study demonstrates the application of PET/CT in a clinical case of CD.