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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Construction of chiral 1,4-DHPs by chiral phosphoric acid catalyzed desymmetric reductive amination
Hong-Guang Chen1, Hao-Yu Peng1, Hao-Wei Peng1
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, China. shunjun@suda.edu.cn.
Abstract:
Herein, we report an asymmetric reductive amination reaction catalyzed by a chiral phosphoric acid, which enables the enantioselective desymmetrization of 1,4-dihydropyridine-3,5-dialdehydes. This reaction features mild conditions, high enantioselectivity, and readily available starting materials. Gram-scale experiments demonstrated that the reaction maintained excellent enantioselectivity, and the product could be readily converted into other chiral 1,4-dihydropyridine derivatives. These results underscore the potential of this method for practical applications.
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