DFDBA plus T-PRF with and without vitamin D3 gel in intrabony defects: a randomized controlled trial

Area of Science:

• Periodontology
• Regenerative Dentistry
• Biomaterials Science

Background:

• Periodontal defects require regenerative approaches for effective therapy.
• DFDBA and T-PRF are used in periodontal regeneration.
• The role of Vitamin D3 in periodontal bone regeneration needs further investigation.

Purpose of the Study:

• To compare the effectiveness of DFDBA plus T-PRF with and without Vitamin D3 gel in treating intrabony periodontal defects.
• To assess clinical and radiographic parameters post-treatment.
• To evaluate the impact of Vitamin D3 on bone regeneration.

Main Methods:

• A split-mouth randomized controlled trial involving 30 patients with stage III Grade B periodontitis.
• Bilateral intrabony defects were treated with either DFDBA plus T-PRF (Group I) or DFDBA plus T-PRF with Vitamin D3 gel (Group II).
• Clinical parameters (PI, GI, PPD, CAL) and CBCT measurements (BDH, VBL, BDD, MDBDW, BLBDW, BDV) were assessed at baseline and 12 months.

Main Results:

• Both groups showed reduction in bone defect depth (BDD) and bucco-lingual bone defect width (BLBDW).
• Group II (with Vitamin D3 gel) demonstrated a significantly greater reduction in BLBDW (2.85 mm) compared to Group I (1.80 mm) (p=0.003).
• No statistically significant differences were found between groups for BDH, VBL, MDBDW, and BDV.

Conclusions:

• Vitamin D3 gel, when combined with DFDBA plus T-PRF, improves bone regenerative outcomes in intrabony periodontal defects.
• This combination therapy offers a promising approach for periodontal regeneration.
• Further research may explore optimal formulations and long-term efficacy.