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Fluorinated Core-Shell Metal-Organic Framework-Based Dual-Activated 19F MRI Nanoprobes for In Vivo Visualization of
Yifan Fan1,2, Yuanxi Zheng1, Xiaoqin Chi3
1State Key Laboratory of Physical Chemistry of Solid Surfaces, the MOE Laboratory of Spectrochemical Analysis & Instrumentation, Fujian Key Laboratory of Chemical Biology, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen361005, China.
This study introduces a novel dual-responsive nanoprobe for in vivo tumor microenvironment visualization using multiplexed 19F MRI. The probe enables enhanced imaging of tumor acidity and phosphate levels, aiding tumor management.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Medical Imaging
Background:
- In vivo visualization of the tumor microenvironment (TME) is essential for understanding tumor progression and guiding treatment.
- Current imaging techniques face limitations in simultaneously tracking dynamic biomarker changes within the TME.
Purpose of the Study:
- To develop a novel dual-responsive nanoprobe for in vivo visualization of the TME.
- To enable multicolor 19F magnetic resonance imaging (MRI) for enhanced TME characterization.
Main Methods:
- Synthesis of a core-shell metal-organic framework (MOF) nanoprobe (Zr@Zn-MOF) responsive to acidosis and inorganic phosphate.
- Utilizing multiplexed 19F MRI for in vivo imaging of the TME.
- Investigating the nanoprobe's signal response to TME-specific stimuli.
Main Results:
- The Zr@Zn-MOF nanoprobe exhibits minimal 19F MRI signals in normal tissues due to strong magnetic dipolar interactions.
- In the TME, low pH and high phosphate trigger nanoprobe degradation, releasing fluorinated ligands and intensifying dual-channel 19F MRI signals.
- The nanoprobe demonstrated effective visualization of the TME with high penetration depth and low background signals.
Conclusions:
- The developed nanoprobe allows for sensitive and specific in vivo visualization of the TME via dual-responsive multicolor 19F MRI.
- This strategy offers a promising approach for advanced imaging-based tumor management.
- Core-shell MOFs are effective platforms for constructing multi-stimuli-responsive 19F MRI nanoprobes.
