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Published on: August 12, 2019
DNA-Compatible α-Aminoamide Synthesis for a DNA-Encoded Library
Juyeon Lee1, Jihoon Lee2, Ik Hwan Choi1
1KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Department of Chemistry, Kyungpook National University, Daegu41566, Republic of Korea.
None:
We report the first direct solution-phase on-DNA Ugi three-component reaction for the selective synthesis of α-aminoamides under mild, DNA-compatible conditions. The optimized reaction provides selective access to the desired products by minimizing competing reaction pathways. The method exhibits broad substrate scope for DNA-conjugated anilines and is applicable to representative DNA-conjugated aldehydes and isocyanides. This work expands the repertoire of DNA-compatible multicomponent reactions and provides access to privileged α-aminoamide scaffolds for DNA-encoded libraries.
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