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Late-Onset Familial Primary Cardiac Angiosarcoma in Two Sisters
Hiroto Kawakami1, Hiroshi Tsuneyoshi1, Shoichi Kyo1
1Department of Cardiovascular Surgery, Shizuoka General Hospital, Shizuoka 420-8527, Japan.
Interdisciplinary Cardiovascular and Thoracic Surgery
|July 21, 2026
Summary
Familial primary cardiac angiosarcoma, a rare cancer, can occur in elderly individuals, not just the young. This finding challenges previous understandings of hereditary cancer syndromes.
Area of Science:
- Cardiology
- Oncology
- Genetics
Background:
- Primary cardiac angiosarcoma is an extremely rare cancer.
- Familial occurrences are uncommon and typically seen in younger individuals, often linked to hereditary cancer syndromes.
Purpose of the Study:
- To report a rare case of familial primary cardiac angiosarcoma in elderly siblings.
- To challenge the conventional understanding of the age of onset for familial cardiac angiosarcoma.
Main Methods:
- Detailed clinical presentation and treatment of two elderly sisters with primary cardiac angiosarcoma.
- Morphological similarity of tumors and anatomical location (right atrium) noted.
Main Results:
- Both elderly sisters developed morphologically similar primary cardiac angiosarcomas in the right atrium.
- The elder sister was diagnosed at age 70, and the younger at age 74, both receiving surgical resection and radiotherapy.
Conclusions:
- Familial primary cardiac angiosarcoma can manifest in advanced age, contrary to previous observations.
- These cases suggest a potential hereditary predisposition for cardiac angiosarcoma that is not limited to younger populations.
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