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Associations between self-reported symptoms and circulating protein biomarkers: A scoping review protocol
Marijane Luistro Jonsson1, Tina Gustavell1,2, Noora Sissala3,4
1Division of Nursing, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Plos One
|July 21, 2026
Summary
This scoping review protocol aims to map associations between self-reported symptoms and protein biomarkers across diseases. By synthesizing existing research, it seeks to uncover shared biological patterns for advancing precision health and symptom science.
Area of Science:
- Integrative biology
- Symptom science
- Proteomics
Background:
- Increasing identification of protein biomarkers necessitates broader reviews beyond disease-specific scopes.
- Current reviews often focus on specific diseases, limiting the discovery of cross-condition biological patterns.
- A diagnosis-agnostic approach can reveal shared symptom-biomarker links, advancing precision health.
Purpose of the Study:
- To consolidate knowledge on self-reported symptom and circulating protein biomarker associations.
- To identify potential cross-disease biological patterns.
- To provide insights for clinical practice and future research in symptom science and proteomics.
Main Methods:
- Scoping review protocol aligned with PRISMA and JBI guidelines.
- Searches across PubMed, CINAHL, Embase, and Web of Science for relevant studies.
- Utilizing AI-assisted tool ASReview for efficient screening of over 30,000 articles.
- Data extraction on symptom-protein biomarker pairs for pattern analysis.
Main Results:
- Protocol registration with Open Science Framework (OSF) ensures transparency and reproducibility.
- Pilot testing of ASReview demonstrated significant time savings and feasibility.
- The review will systematically map and count reported associations between symptoms and biomarkers.
Conclusions:
- This protocol offers a structured approach for a comprehensive, reproducible scoping review.
- Expected results will summarize current knowledge on symptom-biomarker associations.
- The study aims to integrate symptom science and proteomics to advance precision health.