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An Artificial Anion Channel Based on Supramolecular Calix[4]Pyrrole and Its Application as an Anti-Cancer Agent
Hidekazu Miyaji1, Yuki Shiozawa1, Takahiro Matsubara1
1Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, Gifu, Gifu, Japan.
None:
The cis-dipyridylcalix[4]pyrrole palladium(II) complex (cis-DPC+Pd2+) forms a cage-like supramolecular structure that functions as an ion channel, as evidenced by the single ion channel current observations. A lucigenin fluorescence assay revealed that cis-DPC+Pd2+ transports chloride across membranes. The HPTS fluorescence assay revealed that cis-DPC+Pd2+ selectively transports fluoride and chloride. In a cell proliferation assay using THP-1 cells, the cell survival rate with cis-DPC+Pd2+ was lower than that with trans-DPC or trans-DPC+Pd2+. These results suggest that cis-DPC+Pd2+ causes cell death by forming supramolecular pores, allowing the passage of increased numbers of ions.
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