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A Murine Tail Lymphedema Model
Published on: February 10, 2021
Updates on Lymphatic Malformations: Medical Therapies, Sclerotherapy, and Surgery
Michelle Hough1, Dean Anselmo1
1Division of Pediatric Surgery, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA.
None:
Lymphatic malformations represent a diverse group of congenital lymphatic disorders whose management has evolved dramatically with the advent of molecularly targeted therapies. Recognition of the PI3K/AKT/mTOR signaling pathway as a key driver of pathogenesis has transformed treatment, with sirolimus and alpelisib now complementing traditional procedural options. Successful management demands multidisciplinary collaboration, integrating medical, interventional, and surgical involvement and expertise. Continued research into genotype-driven therapy, biomarker development, and long-term outcomes will further refine care for this complex and heterogeneous disease.
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