Related Experiment Video
Updated: Aug 6, 2026

A Real-World High-Intensity Interval Training Protocol for Cardiorespiratory Fitness Improvement
Published on: February 22, 2022
Comparison of high-intensity interval training protocol designs on accumulated time ≥ 90% V̇O₂max: a network
Steffen Held1, Ludwig Rappelt2, Florian Micke3
1Department of Sport and Management, IST University of Applied Sciences, Duesseldorf, Germany. sheld@ist-hochschule.de.
High-intensity interval training (HIIT) protocols do not show clear differences in accumulated time at 90% maximal oxygen uptake (V̇O₂max). Decreased-duration and varied-intensity HIIT ranked highest but require further investigation due to study limitations.
Area of Science:
- Exercise Physiology
- Sports Science
- Cardiovascular Adaptations
Background:
- Accumulated time spent at ≥90% maximal oxygen uptake (V̇O₂max) is a key stimulus for aerobic adaptations during high-intensity interval training (HIIT).
- Understanding the impact of different HIIT protocol structures on this physiological stimulus is crucial for optimizing training.
- Network meta-analysis provides a robust framework for comparing diverse training interventions using direct and indirect evidence.
Purpose of the Study:
- To compare various high-intensity interval training (HIIT) protocol structures based on accumulated time at ≥90% maximal oxygen uptake (V̇O₂max).
- To utilize direct and indirect evidence from controlled HIIT studies in healthy athletes.
- To identify potential differences in physiological stimuli across distinct HIIT programming strategies.
Main Methods:
- Systematic literature search across PubMed, Web of Science, and SPORTDiscus up to January 31st, 2026.
- Inclusion of controlled HIIT studies reporting accumulated time at ≥90% V̇O₂max in healthy athletes.
- Frequentist network meta-analysis (NMA) using standardized mean differences (SMD) with even long intervals as the reference, employing random effects models and assessing heterogeneity and inconsistency.
Main Results:
- Nineteen publications with 20 study units and 240 athletes were analyzed, revealing substantial heterogeneity and inconsistency.
- No significant differences were found between any HIIT approaches and the reference condition (even long intervals) for accumulated time at ≥90% V̇O₂max.
- Decreased-duration (SMD=0.87) and varied-intensity (SMD=0.54) protocols showed the highest point estimates, while 1:1 work-to-rest blocks had the lowest (SMD=-0.68).
Conclusions:
- No specific HIIT protocol structure demonstrated clear superiority in achieving accumulated time at ≥90% V̇O₂max.
- While decreased-duration and varied-intensity protocols ranked higher, these findings are exploratory due to non-significant comparisons, heterogeneity, inconsistency, and sparse data.
- Protocol selection should consider practical factors like feasibility, athlete characteristics, and workload matching over theoretical rankings alone.
Related Concept Videos
Dosage Regimens: Designs and Approaches
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Cardiac Output I:Effect of Heart Rate on Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart rate...
Bioavailability Study Design: Single Versus Multiple Dose Studies
