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Updated: Aug 6, 2026

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
05:34

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Published on: December 16, 2019

Programmable Triple Functionalization of Benzenes by Merging Dearomative Functionalization and Skeletal Editing

Qin He1, Chu-Qiao Li1, Qian Huang1

  • 1State Key Laboratory of Soil Pollution Control and Safety, Department of Chemistry, Zhejiang University, Hangzhou310058, China.

Journal of the American Chemical Society
|July 22, 2026
PubMed
Summary

This study introduces a new method for precisely adding three substituents to simple benzene rings. This programmable approach enables the creation of complex substituted benzenes for medicinal chemistry and materials science.

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