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Updated: Aug 6, 2026

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
Published on: September 13, 2018
Animal virus-host interactions mediated by non-coding RNAs
Zelong Sun1,2, Ye Wang1,2, Zheng Zhou1,2
1Henan Key Laboratory of Precision Diagnosis of Respiratory Infectious Diseases, Zhengzhou Key Laboratory of Precision Diagnosis of Respiratory Infectious Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Abstract:
Non-coding RNAs (ncRNAs) have emerged as key regulators of animal virus-host interactions, such as lncRNAs, miRNAs and circRNAs providing profound insights into host-pathogen interactions and revealing significant potential as biomarkers and therapeutic targets. This review summarizes the interactions between viruses (mainly including animal viruses, zoonotic viruses, insect-vector virus systems and plant viruses) and hosts mediated by lncRNAs, miRNAs, circRNAs and other non-coding RNAs. We focus on the research related to zoonotic disease transmission, non-model animals, aquaculture and animal models, and highlight the critical molecular mechanisms of ncRNAs (including host-derived ncRNAs and viral ncRNAs) in regulating virus-host interactions and their therapeutic potential as antiviral drug targets. In addition, we discuss future research directions and prospects for animal virus-host interactions. Meanwhile, we highlight the application of ncRNA-based RNA vaccines in the animal disease prevention, with the ultimate goal of improving animal health and fostering harmonious coexistence between humans and animals.
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