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Cytomegalovirus (CMV) Co-infection in Treatment-Refractory Immune Checkpoint Inhibitor-Associated Colitis: A Case
Michael Stanczyk1, Xiaobang Hu1
1Department of Pathology and Laboratory Medicine, Penn State College of Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, USA.
Immune checkpoint inhibitor (ICI) therapy can cause colitis. In a patient with metastatic melanoma, cytomegalovirus (CMV) co-infection was identified as a cause of refractory ICI-associated colitis, leading to improved outcomes with ganciclovir treatment.
Area of Science:
- Oncology
- Gastroenterology
- Immunology
Background:
- Immune checkpoint inhibitors (ICIs) are vital in cancer therapy but can induce colitis.
- ICI-associated colitis is a frequent adverse event requiring careful management.
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