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Severe diarrhea secondary to propranolol.
Southern Medical Journal
|March 1, 1979
Summary
Severe diarrhea can be a side effect of propranolol, a common beta-blocker medication. This adverse drug reaction was confirmed by drug rechallenge and resolved upon discontinuation in two patients.
Area of Science:
- Pharmacology
- Gastroenterology
Background:
- Propranolol is a widely prescribed beta-adrenergic receptor antagonist.
- Gastrointestinal side effects are known but severe diarrhea is less common.
Observation:
- Two patients presented with severe diarrhea.
- The diarrhea was temporally associated with propranolol use.
Findings:
- Drug rechallenge confirmed propranolol as the causative agent for severe diarrhea in both cases.
- Discontinuation of propranolol led to rapid resolution of diarrhea.
Implications:
- Clinicians should consider propranolol as a potential cause of severe diarrhea.
- Awareness of this adverse drug reaction can aid in timely diagnosis and management.