Related Experiment Video
Updated: Aug 6, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
[Inherited epidermolysis bullosa in Dakar : Descriptive cross-sectional study of 36 cases]
Mame Tene Ndiaye Diop1, Khadim Diop2, Birame Seck3
1Department of Dermatology, Department of Paediatrics, National Children's Hospital Albert Royer, Department of Dermatology, PO Box 25755 Dakar, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University of Dakar, Fann, Senegal.
Introduction:
The aim of this study was to determine the frequency, clinical forms and complications of Inherited epidermolysis bullosa in Dakar.
Methodology:
we conducted a descriptive cross-sectional study with data collection from medical records of patients followed up for Inherited epidermolysis bullosa in the dermatology department of the Albert Royer Children's Hospital over an 11-year period.
Results:
36 patients were registered, representing a hospital frequency of 0.16% and a sex ratio of 0.6. Clinical forms were: dystrophic in 44%, simple in 33%, junctional in 17%, associated with congenital cutaneous aplasia in 6% (Bart's syndrome), Kindler's syndrome in 6%. Complications occurred in 39% of cases, including infections in 28%, hemodynamic disorders in 17% and digestive complications in 11%. Death was recorded in 11% as a result of infectious and anemia.
Conclusion:
We report a series of 36 cases of inherited epidermolysis bullosa, representing a hospital frequency of 0.16%. The most frequent clinical form is dystrophic. Complications are mainly infectious and hemodynamic. We emphasize the importance of follow-up in these patients, given the risk of skin cancer associated with the long-term prognosis of scars in dystrophic forms.
Related Concept Videos
Clinical Applications of Epidermal Stem Cells
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Desmosomes
Pedigree Analysis
Renewal of Skin Epidermal Stem Cells