Carbonic anhydrase XIV
Giuseppina De Simone1, Vincenzo Alterio1
1Institute of Biostructures and Bioimaging, CNR, Naples, Italy.
The Enzymes
|July 22, 2026
Summary
Carbonic Anhydrase XIV (CA XIV) is a membrane-associated enzyme with significant physiological roles. Research highlights its potential as a therapeutic target for various diseases, though selective inhibitors are still under development.
Area of Science:
- Biochemistry
- Molecular Biology
- Enzymology
Background:
- The carbonic anhydrase (CA) family includes numerous isozymes with diverse functions.
- Carbonic Anhydrase XIV (CA XIV) is a membrane-associated enzyme.
- Mammals possess sixteen characterized CA isozymes, with additional isoforms in other vertebrates.
Purpose of the Study:
- To provide an overview of the biochemical and structural characteristics of CA XIV.
- To highlight the functional properties and physiological significance of CA XIV.
- To discuss the mechanisms regulating CA XIV activity and its role in health and disease.
Main Methods:
- Literature review of biochemical and structural data.
- Analysis of functional properties and physiological relevance.
- Examination of regulatory mechanisms and therapeutic potential.
Main Results:
- CA XIV is a membrane-associated enzyme with specific biochemical and structural features.
- Its physiological significance extends to various health and disease states.
- CA XIV is an emerging target for drug discovery, with ongoing research into selective inhibitors.
Conclusions:
- CA XIV plays a crucial role in various physiological processes.
- Its involvement in disease makes it a promising therapeutic target.
- Further research is needed to develop selective CA XIV inhibitors for drug discovery.
Keywords:
CA XIVCarbonic anhydrase XIVEnzyme inhibitorsMembrane-associated enzymesZinc metalloenzymesα-carbonic anhydrasesMore Related Videos
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