Carbonic anhydrase III
1NEUROFARBA Department, Section of Pharmaceutical Sciences, University of Florence, Sesto Fiorentino, Italy.
The Enzymes
|July 22, 2026
Summary
Carbonic anhydrase III (CA III), a low-activity enzyme, is vital for redox balance and metabolism in tissues like muscle and liver. It plays key roles in antioxidant defense, lipid metabolism, and has links to cancer development.
Area of Science:
- Biochemistry and Molecular Biology
- Physiology
Background:
- Carbonic anhydrase III (CA III) is a cytosolic isozyme with low catalytic activity.
- It is abundantly expressed in skeletal muscle, liver, and adipose tissue.
- CA III is implicated in maintaining redox homeostasis, metabolism, and cell survival.
Purpose of the Study:
- To review the discovery, structure, and catalytic properties of CA III.
- To elucidate the physiological roles of CA III in various tissues.
- To discuss the associations of CA III with disease processes, including cancer.
Main Methods:
- Literature review and synthesis of existing research on CA III.
- Analysis of structural and functional data.
- Examination of physiological and pathological studies involving CA III.
Main Results:
- CA III is a multifunctional protein involved in antioxidant defense, lipid metabolism, and adipogenesis.
- It plays a role in tissue repair mechanisms.
- CA III is associated with various disease processes, notably cancer.
Conclusions:
- CA III is a significant protein with diverse physiological functions beyond its enzymatic activity.
- Its involvement in fundamental cellular processes highlights its importance in health and disease.
- Further research into CA III's multifaceted roles is warranted.
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