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Dual-Template Mesoporous Bioactive Glass with Optimized Pore Structure Improve BMP2 Delivery in a Cryogel System for
Haorui Peng1,2, Yulin Zhang1,2, Qiyuan Dai1,2
1Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou510006, China.
ACS Applied Bio Materials
|July 23, 2026
Summary
This study developed a novel chitosan composite cryogel with enhanced bioactive glass for bone repair. The material effectively controls bleeding and promotes bone regeneration, offering a promising solution for traumatic bone injuries.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Orthopedic Engineering
Background:
- Bone injuries require materials for both hemorrhage control and osteogenesis.
- Current treatments often lack integrated hemostatic and osteogenic capabilities.
Purpose of the Study:
- To fabricate and evaluate a chitosan-based composite cryogel incorporating dual-template mesoporous bioactive glass (dMBG) and bone morphogenetic protein 2 (BMP2).
- To assess the material's hemostatic properties, mechanical stability, degradation profile, and osteogenic potential for treating bone defects.
Main Methods:
- Fabrication of a chitosan-BG/BMP2 composite cryogel using a dual-template method for dMBG.
- Evaluation of mechanical properties (compressive strength, cyclic compression), degradation kinetics, and hemocompatibility.
- In vitro assessment of the composite's effect on bone marrow mesenchymal stem cells (BMSCs) migration and osteogenic differentiation.
Main Results:
- The cryogel demonstrated good mechanical strength (>20 kPa), controlled degradation, and hemocompatibility.
- dMBG incorporation enhanced hemostatic efficacy and biocompatibility.
- The composite significantly promoted BMSC migration and osteogenic differentiation, evidenced by increased ALP activity, calcium nodule formation, and osteogenesis-related gene expression.
Conclusions:
- The developed multifunctional cryogel integrates hemostasis, structural support, and osteogenic bioactivity.
- This biomaterial shows significant potential for the clinical treatment of hemorrhagic bone defects.
