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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Eosinophilia in Pulmonary Practice
Anil N Nair1, A Arthi, V Jereen
1Department of Respiratory Medicine, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, India.
Annals of African Medicine
|July 23, 2026
Summary
Pulmonary eosinophilia, an increase in eosinophils in the lungs, is linked to diverse respiratory conditions. A systematic approach is key for diagnosing and managing these eosinophilic lung diseases effectively.
Area of Science:
- Pulmonary Medicine
- Immunology
- Pathology
Background:
- Eosinophilia is a common lab finding in respiratory diseases, impacting host defense and causing inflammatory lung conditions.
- Diagnosing pulmonary eosinophilia is challenging due to varied causes and overlapping symptoms.
Purpose of the Study:
- To review the causes, pathophysiology, clinical spectrum, diagnostic methods, and management of pulmonary eosinophilia.
- To provide a comprehensive overview for clinicians managing patients with eosinophilic lung diseases.
Main Methods:
- A narrative literature review was conducted using PubMed, Scopus, and Google Scholar.
- Keywords included "eosinophilia," "pulmonary eosinophilia," "eosinophilic lung diseases," "asthma," and "hypereosinophilic syndrome."
- Included original research, guidelines, and reviews focusing on respiratory eosinophilia; excluded non-pulmonary or irrelevant studies.
Main Results:
- Pulmonary eosinophilia stems from allergic diseases (asthma, ABPA), infections, drug reactions, autoimmune disorders, and primary eosinophilic pneumonias.
- Clinical presentations range from mild symptoms to severe respiratory failure.
- Diagnosis relies on peripheral blood eosinophilia, imaging, and bronchoalveolar lavage, requiring differentiation of primary vs. secondary causes.
Conclusions:
- Eosinophilia is a critical diagnostic clue in respiratory medicine, necessitating a structured evaluation.
- Timely identification of the cause is vital for appropriate management and complication prevention.
- Understanding eosinophil biology and targeted therapies promise improved outcomes for eosinophilic lung diseases.
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