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Published on: October 28, 2015
Modularized GSH-Proton Tandem-Responsive "Off-Brighter" Persistent Luminescent Nano-System for Visualized Synergetic
Chang Yin1, Kai Long1, Xinxin Yuan1
1Key Laboratory of Functional Polymer Materials of the Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, China.
Abstract:
Visualized theranostics is a powerful tool for guiding cancer diagnosis, therapy, and prognosis through medical imaging; nevertheless, simultaneously achieving high imaging contrast, reliable therapeutic efficacy, inter-component cooperativity, and broad methodological versatility with a facile strategy remains exceedingly challenging. For the first time, this study introduces a novel modular "Off-Brighter" persistent luminescence (PersL) theranostic strategy for visualized cancer therapy. The nano-agent integrates two functional modules: a proton-responsive PersL imaging brick (ZR) optimized via dye-sensitization, and a GSH-responsive synergistic photothermal/chemodynamic therapy brick (PAHIR-Fcss) loaded with IR808 and FcSH. FcSH temporarily quenches ZR's PersL, creating "GSH-proton" tandem-responsive "Off-Brighter" activation that enhances luminescence 12.3-fold and achieves tumor imaging contrast of 274.95. Real-time imaging guided drug delivery monitoring, identifying the 3rd h post-injection as optimal for combination therapy. The synergistic photothermal/chemodynamic approach attained 96.2% tumor suppression in murine breast cancer models. Subsequent PersL imaging-based assessment determined that a single 14-day treatment course optimizes efficacy while preventing overtreatment risks. The modular design enables free exchange of imaging and therapeutic components, offering a versatile, generalizable platform for tailored clinical applications.
