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The Association Between Potential Nuclear Factor-Kappa B1 Gene Polymorphism rs28362491 and miR-206 Level in Patients

Isra Muradi1, Jehad Alhmoud1, Moath Al-Qaraleh1

  • 1Medical Laboratory Sciences, Al-Ahliyya Amman University, Al-Salt, Jordan.

World Journal of Oncology
|July 23, 2026
PubMed
Abstract

Insights

Reduced miR-206 expression may act as a tumor suppressor in acute lymphoblastic leukemia (ALL). The NF-κB1-94 ATTG polymorphism

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • MicroRNAs (miRNAs) and the nuclear factor-kappa B1 (NF-κB1) pathway are crucial in leukemogenesis.
  • The miR-206 and NF-κB1-94 ATTG polymorphism (rs28362491) may influence cancer progression and treatment outcomes.

Purpose of the Study:

  • To evaluate miR-206 expression levels in patients with acute lymphoblastic leukemia (ALL) and Hodgkin lymphoma (HL) compared to controls.
  • To determine the genotypic distribution of the NF-κB1-94 ATTG polymorphism in these groups.
  • To assess the relationship between miR-206 expression, NF-κB1 genotypes, and clinical outcomes in leukemia patients.

Main Methods:

  • A retrospective case-control study involving ALL (n=46), HL (n=35), and healthy controls (n=30).
  • Quantitative real-time polymerase chain reaction (qRT-PCR) was used to measure miR-206 expression.
  • PCR and sequencing determined NF-κB1-94 ATTG polymorphism genotypes from tissue and blood samples.

Main Results:

  • miR-206 expression was significantly lower in ALL and HL patients compared to healthy controls, suggesting a tumor suppressor role.
  • The homozygous Ins/Ins genotype of NF-κB1 (rs28362491) was more prevalent in ALL patients than controls.
  • No significant correlation was found between miR-206 levels and NF-κB1 genotypes or remission status.

Conclusions:

  • No significant difference in miR-206 expression was observed across different NF-κB1-94 ATTG genotypes.
  • Reduced miR-206 expression may function as a tumor suppressor in ALL.
  • The NF-κB1 polymorphism did not significantly affect remission status in ALL patients, but both factors may serve as potential biomarkers.
Keywords:
Acute lymphoblastic leukemiaHodgkin lymphomaNF-κB1-94 ATTG polymorphismmiR-206

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