Related Experiment Video
Updated: Aug 6, 2026
08:04
Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging
Published on: April 14, 2011
TREATMENT OF BENIGN LYTIC BONE LESIONS WITH 45S5 BIOACTIVE GLASS: A CASE SERIES
Jaime Gomes Nogueira1, Marco de Andrade Bianchi1, André Ferrari de França Camargo1
1Universidade de Sao Paulo, Faculdade de Medicina, Hospital das Clinicas, Instituto de Ortopedia e Traumatologia IOT-HCFMUSP, Sao Paulo, SP, Brazil.
Acta Ortopedica Brasileira
|July 23, 2026
Summary
This study shows that 45S5 bioactive glass is effective for treating benign cavitary bone lesions. It provides good bone healing and osseointegration with few complications after intralesional resection.
Area of Science:
- Orthopedic Surgery
- Biomaterials Science
- Bone Regeneration
Background:
- Benign cavitary bone lesions require effective treatment to restore bone integrity.
- Intralesional resection (curettage) is a common surgical approach.
- Bone void filling is crucial after curettage to promote healing and stability.
Purpose of the Study:
- To evaluate the efficacy of 45S5 bioactive glass (Aktibone) as a bone substitute.
- To assess outcomes following intralesional resection and bioactive glass filling for benign cavitary lesions.
- To report on osseointegration and complication rates in a case series.
Main Methods:
- Therapeutic case series (Level IV evidence).
- Nine patients with benign lytic bone lesions underwent curettage and cavity filling with 45S5 bioactive glass.
- Postoperative imaging evaluated radiological diagnosis and osseointegration quality.
Main Results:
- Nine patients (7 males, 2 females; mean age 25.8 years) were included.
- Enchondromas were the most frequent diagnosis.
- Mean follow-up was 8.4 months, with good clinical progression and osseointegration observed in most patients.
Conclusions:
- 45S5 bioactive glass demonstrates good performance as a bone substitute for benign lytic lesions.
- Adequate osseointegration and a low complication rate were achieved.
- Bioactive glass is a viable option for filling bone voids after curettage.