Related Experiment Video
Updated: Jun 18, 2026
06:53
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
Published on: September 9, 2020
2.6K
SURVIVAL AND COMPLICATIONS ASSOCIATED WITH UNCONVENTIONAL ENDOPROSTHESIS RECONSTRUCTIONS FOR PRIMARY BONE TUMORS AND
Daniel César Seguel Rebolledo1, Rodrigo DA Silva Cordeiro2, André Mathias Baptista2
1Instituto do Cancer do Estado de São Paulo, São Paulo, SP, Brazil.
Acta Ortopedica Brasileira
|April 10, 2025
Summary
Unconventional stent reconstructions for bone and soft tissue tumors show survival depends on cancer type and patient health. Complications are linked to smoking, functionality, and comorbidities.
Area of Science:
- Oncology
- Surgical Oncology
- Biomedical Engineering
Background:
- Unconventional stent reconstructions are used for bone and soft tissue tumors.
- Evaluating survival and complications is crucial for patient outcomes.
Purpose of the Study:
- To assess survival rates and postoperative complications following unconventional stent reconstructions.
- To identify risk factors influencing outcomes in patients with bone and soft tissue tumors.
Main Methods:
- Retrospective data extraction from the Instituto do Cancer do Estado de São Paulo (ICESP) registry.
- Analysis of 108 patients undergoing unconventional stent reconstruction surgeries.
- Evaluation of complications including thrombosis, amputation, infection, recurrence, and death, alongside survival times.
Main Results:
- Significant associations found between smoking and tumor recurrence.
- Cancer type, patient functionality, and hypertension correlated with postoperative complications and death.
- Patients with soft tissue tumors or limited functionality faced higher risks of earlier complications.
Conclusions:
- Cancer type, patient functionality, comorbidities, stent location, and treatment exposure (chemo/radiotherapy) are key risk factors.
- These factors significantly impact complications and survival after unconventional stent reconstruction.
- Understanding these risks can inform surgical planning and patient management.
More Related Videos
Related Concept Videos
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
01:27Fractures: Bone Repair
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:31Bone Remodeling and Repair
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
01:24Tissue Transplantation
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...