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Updated: Aug 6, 2026
Senescence Detection Using Reflected Light in Adipose Stromal Vascular Fraction
Published on: June 5, 2026
Exposure to polystyrene nanoplastics provokes vascular endothelial senescence through eliciting nucleolar stress
Linjuan Wang1, Yiqi Wan2, Lihai Wu3
1Pathology Center of the First Affiliated Hospital of Nanchang University/Jiangxi Provincial Key Laboratory of Precision Pathology and Intelligent Diagnosis, Nanchang University, Nanchang 330006, China; Pathology Teaching and Research Office, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang 330006, China.
Abstract:
Polystyrene nanoplastics (PS-NPs) are emerging environmental contaminants with unclear cardiovascular impacts. This study evaluated PS-NPs-induced endothelial senescence using murine models and HUVECs. PS-NPs caused aortic wall thickening and structural disruption in mice, and induced DNA damage, apoptosis, cell cycle arrest, and impaired migration/vasculogenesis in vitro. Both models showed excessive ROS production and nucleolar stress (NPM1 relocalization), leading to premature senescence via p53/p21 upregulation. These effects were reversed by NPM1 inhibitor NSC348884 or ROS scavenger N-acetylcysteine. Collectively, PS-NPs promote vascular endothelial senescence through ROS-dependent nucleolar stress, highlighting their vasotoxic potential and cardiovascular risks.
