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Updated: Aug 6, 2026

Microfluidic Dry-spinning and Characterization of Regenerated Silk Fibroin Fibers
Published on: September 4, 2017
Structural characterization and functional properties of silk fibroin/ sericin derived from silkworm cocoons of
Chenchen Jiang1, Funi Chen2, Yang Xiao2
1Guangdong Academy of Agricultural Sciences, Sericultural & Agri-Food Research Institute, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou, 510610, China; School of Food Science and Engineering, Foshan University, Foshan, 528225, China.
Abstract:
Silk fibroin (SF) and silk sericin (SS), the two main natural polymer components of silk, exhibit structural and functional variations influenced by intrinsic molecular characteristics and coloration-associated factors of cocoons. This study prepared SF and SS from white, yellow, and green naturally colored cocoons, systematically comparing their structural and functional properties via multi-characterization techniques (XRD, DSC, FTIR, SEM) and functional assays (UV shielding, T-AOC, tyrosinase inhibition). Results showed SF primarily comprised Silk II β-sheet crystalline regions with higher crystallinity, thermal stability, and a dense fibrous/lamellar structure, exhibiting stronger tyrosinase inhibitory activity (white SF optimal). SS, dominated by random coils, formed loose amorphous aggregates, with markedly superior UV-shielding and antioxidant capacities showing a color-dependent trend of green > yellow > white. This work clarifies hierarchical structural differences between SF and SS from differently colored cocoons and their impacts on optical/biological functionalities, providing experimental and theoretical support for graded silk protein utilization, functional material design, and high-value development of naturally colored cocoon resources.
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