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Cyclodextrin-mediated delivery of resveratrol: Recent advances, therapeutic potential, and future perspectives
Raheleh Boroumand1, Atoosa Haghighizadeh1, Zahra Salmasi2
1Department of Pharmaceutical and Food Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract:
Resveratrol (RES) is a naturally occurring polyphenol with established antioxidant, anti-inflammatory, anticancer, and cardioprotective properties. However, low aqueous solubility, poor chemical stability, fast metabolism, and low oral bioavailability severely restrict its clinical translation. Cyclodextrins (CDs) and their derivatives, which act as host molecules, can be improved the solubility, stability, and therapeutic efficacy of RES by formation inclusion complexes (ICs). In addition to conventional CDs/RES ICs, various advanced delivery platforms, including CDs-based nanosponges, hybrid nanosystems, and topical/transdermal formulations have demonstrated encouraging outcomes in recent years in terms of enhancing biological activity and modifying release kinetics. Accordingly, a comprehensive understanding of CDs-based platforms for optimizing RES delivery and therapeutic application is necessary. This review highlights the physicochemical basis of the CDs-RES interaction, the mechanisms underlying improved bioavailability, and the effectiveness of CDs-based systems in both in vitro and in vivo models. Moreover, current challenges and future perspectives are discussed to highlight the potential of CDs-enabled strategies for optimizing RES delivery and therapeutic performance.
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