Roles of Piezo channels in dentofacial deformity: Onset, orthodontic treatment, and associated diseases

The onset and treatment of dentofacial deformities are closely associated with mechanical stimuli. As mechanosensitive ion channels, Piezo channels play a critical role in the mechanotransduction processes of various tissues and organs, including the craniofacial skeleton and periodontium. This review comprehensively examines the significant role of Piezo channels in dentofacial deformities, addressing their pathogenesis, orthodontic treatment, and the progression of related diseases. It synthesizes evidence that highlights the clinical importance of targeting Piezo channels, which can simultaneously facilitate orthodontic tooth movement, manage treatment complications, and control pain. This work enhances our understanding of the etiology of dentofacial deformities and serves as a valuable reference for clinical orthodontic practice.