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FDA-Approved Drugs Containing Amide Functionality in the Last Five Years (2021-2025): Pharmaceutical Use, Trends and
1Laboratory of Molecular Logic Gates, Department of Chemistry, Faculty of Science, University of Malta, MSD 2080 Msida, Malta.
Medicines (Basel, Switzerland)
|July 24, 2026
Summary
The amide functional group is crucial in modern drug design. Recent FDA-approved therapeutics demonstrate its versatility in antiviral and oncology applications, highlighting its essential role in medicinal chemistry.
Area of Science:
- Medicinal Chemistry
- Drug Discovery
- Organic Chemistry
Background:
- The amide functional group is a fundamental scaffold in medicinal chemistry.
- Its role in drug design is critical for developing modern therapeutics.
- This review focuses on amide-containing drugs approved between 2021 and 2025.
Purpose of the Study:
- To analyze FDA-approved drugs containing amide functionality from 2021-2025.
- To highlight the evolving and versatile role of the amide bond in novel therapeutics.
- To detail synthetic routes and amide-forming strategies for drug discovery.
Main Methods:
- Review of FDA-approved drugs (small molecules and peptides < 1300 Da) between 2021-2025.
- Analysis of amide bond functionality in antiviral and oncology agents.
- Examination of synthetic pathways and amide formation techniques.
Main Results:
- Amide bonds are integral to peptidomimetics in antiviral drugs (e.g., nirmatrelvir).
- Amides serve as stable linkers in precision oncology drugs (e.g., adagrasib).
- The amide group's properties (planarity, stability, H-bonding) are key to its utility.
Conclusions:
- The amide bond remains an essential element in medicinal chemistry.
- Its versatility supports next-generation therapeutics in oncology, infectious diseases, and neurology.
- Understanding amide formation is vital for practical drug discovery frameworks.
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