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Updated: Aug 6, 2026

A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro
Published on: August 27, 2015
Multiscale Analysis of a Kinetic Equation for Mechanotaxis
Benoît Perthame1, Francesco Salvarani2,3, Shugo Yasuda4
1Sorbonne Université, CNRS, Université de Paris Cité, Inria, Laboratoire Jacques-Louis Lions, F-75005, Paris, France.
Abstract:
We present a new kinetic equation for cell migration driven by mechanical interactions with the substrate, an effect not previously captured in kinetic models, and essential for explaining observed collective behaviors such as those in bacterial colonies. The model introduces an acceleration term that accounts for the dynamics of motile cells undergoing mechanotaxis, where extracellular signals modulate the forces arising from cell-substrate interactions. From this formulation, we derive a family of macroscopic limit equations and analyze their principal properties. In particular, we examine linear stability and pattern formation ability through theoretical analysis, supported by numerical simulations.
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