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Updated: Aug 6, 2026

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
Published on: June 2, 2022
Forever chemicals, the microbiome, and brain health: towards therapeutics
Dhirendra Pratap Singh1, Eileen Ryan2, Gerard Clarke3
1APC Microbiome Ireland, University College Cork, Cork, Ireland; ICMR-National Institute of Occupational Health Research (NIOHR), Meghani Nagar, Ahmedabad, Gujarat 380016, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Abstract:
Per- and polyfluoroalkyl substances (PFAS) are persistent xenobiotics linked to neurodevelopmental, neurodegenerative, and neurological disorders. PFAS-induced gut microbiota remodelling may disrupt gut-brain signalling, thereby affecting brain functions and behaviour. Integrating microbiome endpoints (diversity, taxonomic shifts, and metabolic configuration) into PFAS research provides a framework to elucidate toxicodynamic mechanisms and to inform the development of targeted, mechanism-based therapeutic strategies.
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