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Updated: Aug 5, 2026
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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Dual Photoredox/NHC Catalysis with a Renewable Feedstock: Accessing Quaternary γ-Amino Ketones from Proline
Xuewei Hou1, Ruiying Ma1, Fei Yuan1
1State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin300071, People's Republic of China.
Abstract:
A mild and efficient dual photoredox/NHC catalytic system is developed for the synthesis of γ-amino ketones from naturally sourced proline derivatives, alkenes, and aryl carboxylic acids. This three-component radical coupling constructs two new C-C bonds in a single operation, affording a range of quaternary γ-amino ketones in moderate to excellent yields with broad substrate scope and good functional group tolerance. The reaction operates under mild, room-temperature conditions and uses renewable proline feedstocks. Gram-scale synthesis further demonstrates the scalability and practicality of this green protocol.
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