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Ga/Zn Single-Atom Nanozyme-Based Colorimetric Sensor Array for High-Throughput Identification of Tetracyclines
Shuang Liang1, Dongyao Chen2, Liming Ma1
1Department of Chemistry, Capital Normal University, Beijing 100048, China.
Analytical Chemistry
|July 27, 2026
Summary
This study developed a novel sensor array using single-atom nanozymes to detect tetracycline (TC) residues. The method efficiently differentiates and quantifies seven TCs in environmental samples, ensuring public health and ecosystem safety.
Area of Science:
- Environmental Chemistry
- Nanotechnology
- Analytical Chemistry
Background:
- Tetracycline (TC) residues in the environment present significant risks to ecosystems and public health.
- Efficient and convenient detection methods for TCs are urgently needed.
Purpose of the Study:
- To develop a novel sensor array for the sensitive and selective detection of tetracycline residues.
- To utilize single-atom nanozymes for differentiating and quantifying various TCs.
Main Methods:
- Preparation of Gallium/Zinc (Ga/Zn) single-atom (SA) nanozymes with peroxidase-like activity.
- Construction of a three-channel colorimetric sensor array based on differential inhibition of TC residues.
- Application of linear discriminant analysis and machine learning algorithms (e.g., random forests) for data analysis.
Main Results:
- The sensor array successfully differentiated and quantified seven TCs within the range of 1 nM to 100 μM.
- Accurate identification and prediction of TCs in blind and real environmental samples were achieved.
- The Ga/Zn NC SA nanozymes exhibited distinct inhibitory effects on different TCs, enabling selective detection.
Conclusions:
- The developed sensor array offers a new, efficient method for differentiating and detecting TC residues in complex samples.
- This approach holds significant promise for environmental monitoring and food safety applications.
- The study highlights the potential of single-atom nanozymes in developing advanced analytical tools.
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