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Updated: Aug 5, 2026
07:50
Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
Inverse Association of p63 Expression with Hormone Receptor Status in Invasive Breast Cancer
Panagis Lykoudis1, Maria Papadoliopoulou2, Alexios Kozonis2
1Department of Pathology, Imperial College London, London SW2 1NY, UK.
Journal of Personalized Medicine
|July 27, 2026
Summary
p63 gene expression in breast cancer is inversely linked to estrogen and progesterone receptor status. This finding may influence diagnostic and treatment strategies for breast cancer patients.
Area of Science:
- Oncology
- Molecular Pathology
Background:
- Immunohistochemistry is crucial for breast cancer diagnosis, characterization, and treatment decisions.
- p63 gene expression is being investigated for its diagnostic and prognostic value in breast cancer.
Purpose of the Study:
- To evaluate p63 gene expression in invasive breast carcinoma.
- To compare p63 expression with various clinicopathological factors.
Main Methods:
- Analysis of 127 invasive breast carcinoma specimens and 50 control cases.
- Assessment of p63 gene expression using immunohistochemistry.
- Correlation analysis with factors including receptor status, tumor size, grade, and HER2 status.
Main Results:
- No p63 expression was detected in control cases.
- A significant negative correlation was found between p63 expression and both estrogen receptor (ER) and progesterone receptor (PR) status (p=0.005 and p=0.017).
- Tumor size showed a marginally non-significant correlation (p=0.051); other factors, including HER2 status, were not significantly correlated.
Conclusions:
- p63 expression is inversely correlated with ER and PR status in breast cancer.
- Tumor type, size, grade, and HER2 status do not correlate with p63 expression.
- Findings may impact genotype-based stratification for breast cancer diagnosis and personalized treatment.
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