ASO Practice Guidelines Series: Resectable Colorectal Cancer

Area of Science:

• Oncology
• Gastroenterology
• Cancer Research

Background:

• Colorectal cancer (CRC) is a significant global health burden.
• Distinct biological and clinical features necessitate separate management for colon and rectal cancers.
• Evolving molecular characterization and treatment paradigms, including neoadjuvant therapy and organ preservation, are transforming CRC care.

Purpose of the Study:

• To summarize current international guidelines for colorectal cancer management.
• To highlight recent advancements and areas of debate in CRC treatment strategies.
• To provide a guideline-anchored resource for clinical decision-making.

Main Methods:

• Comparative analysis of contemporary guidelines from NCCN, ESMO, and JSCCR.
• Review of recent literature on molecular characterization (e.g., mismatch repair status).
• Synthesis of information on neoadjuvant therapies and organ-preservation approaches.

Main Results:

• Identification of key differences in colon versus rectal cancer management.
• Summary of updated recommendations based on molecular profiling and treatment innovations.
• Outline of evolving strategies in neoadjuvant treatment and organ preservation.

Conclusions:

• Standardized, guideline-driven approaches are crucial for optimal colorectal cancer care.
• Ongoing research and guideline evolution are essential to address emerging challenges in CRC management.
• Personalized treatment strategies informed by molecular data and international best practices are key.